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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are typically described as focusing on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and had participants from different geographic areas. This type of heterogeneity, which is vital for pragmatic trials to be valid and reduce bias in results is also essential. However too much heterogeneity could cause issues with the design of the trial.

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The goal of pragmatic trials is to replicate real-life situations and achieve maximum credibility externally. They are usually commissioned by policy makers and practitioners to inform their decision making. They are also a good method of determining the causal relationship between an intervention and its results. However, they should not be used to substitute for the use of explanation trials.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis as well as pragmatic trials that inform the practice and policy decisions. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a practical trial which includes recruitment, design and delivery of the intervention, and the follow-up.

The number of pragmatic trials is growing. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), 프라그마틱 무료스핀 홈페이지 (https://perfectworld.wiki) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember that the majority of these trials were conducted in primary care settings.