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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically characterized by a focus on the practical aspects of study design, such as the recruitment and consent process in adherence, as well as the use of commonly available equipment.

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Pragmatic is a software company offers a range of casino games to online gambling platforms. Its iGaming solutions are used by the top operators and casinos that are located in the land. The company offers front-end website design tools, analysis tools and promotions, marketing security payment systems, customer support and bug reporting. The company also provides security, high-quality graphics, gameplay and security.

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A practical trial that employs various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for practical trials to be valid and also helps reduce bias in the results. A high degree of heterogeneity, however could cause issues with the design of the trial.

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Pragmatic Play offers not only mobile-friendly slot machines as well as live casino and table games. Pragmatic Play is licensed and regulated by a variety of authorities, including the Malta Gaming Authority and UK Gambling Commission. The games are supported by top-of-the-line encryption technology and the security team is available to assist players with any issues they might face.

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Pragmatic Play is known for its top-notch games, and also for providing an outstanding user experience. The software is available on mobile devices as well as in various languages. It has been recognized as one of the top casino gaming platforms despite its relative infancy. Wolves is one of the latest games that is a 5-reel slot machine that has a high RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to mimic real-life scenarios and gain maximum validity externally. They are typically commissioned by practitioners and policy makers to guide their decision-making. They can also be used to determine the causal relationship between an intervention and its results. They should, however, not be used to replace explanation studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis, and pragmatic trials, which inform the practice and policy decisions. They also suggested the framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a practical trial that include the recruitment process, the design and delivery of the intervention, as well as follow-up.

There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the subject of pragmatic thinking. However, it is important to note that the majority of these trials were conducted in primary care settings.